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CasNo: 154992-24-2
Molecular Formula: C17H18F3N3O3
Description |
RU58841, also known as PSK-3841 or HMR-3841, is a potent androgen receptor inhibitor developed by the French pharmaceutical company Roussel Uclaf. It is classified as a nonsteroidal antiandrogen (NSAA) and is primarily used to treat androgenetic alopecia, commonly known as male pattern baldness. |
Uses | RU58841 has been shown to effectively inhibit the hair-thinning effects of DHT, increase the percentage of hair growth in the anagen phase, and improve hair density and diameter. Unlike some other antiandrogen medications, RU58841 is believed to have minimal systemic side effects, making it a promising treatment option for androgenetic alopecia. In addition to its use in treating male pattern baldness, RU58841 has been investigated for potential applications in other androgen-dependent conditions such as acne and excessive hair growth. Its chemical structure is similar to other NSAAs such as nilutamide, flutamide, bicalutamide, and enzalutamide. |
InChI:InChI=1/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
RU58841 is active against baldness and i...
When applied topically on the ventral pinna of sexually mature male Syrian hamsters for 4 weeks, RU 58841 produced a dose dependent decrease in SG size, with maximum reduction of 60% occurring at a dose of 10 μg per day. The long-haired Syrian hamster (LHS) hamster carries a recessive mutation (ll / ll) of the hair coat. Hair growth in the LHS hamster is sexually dimorphic and androgen dependent.
In intact rats, no effects were observed up to 1 mg animal whatever the route of administration. These results suggest that RU 58841 might be useful for the topical treatment of androgen-dependent skin disorders such as acne, androgenic alopecia and hirsutism.
4-Bromobutyl acetate
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
4-amino-2-trifluoromethylbenzonitrile
2-bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methylpropanamide
4-(4,4-dimethyl-2,5-dioxo-3-(4-iodobutyl)-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile
bis-2-propyl carbonate
dicyclohexyl carbonate