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RU 58841

  • Product Name: RU 58841
  • CasNo: 154992-24-2
  • Purity:
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CasNo： 154992-24-2

Molecular Formula： C17H18F3N3O3

Factory Supply High Purity RU58841 154992-24-2 Lowest Price and Fast Shipping

  • Molecular Formula:C17H18F3N3O3
  • Molecular Weight:369.343
  • Vapor Pressure:1.47E-10mmHg at 25°C 
  • Refractive Index:1.559 
  • Boiling Point:493.588 °C at 760 mmHg 
  • PKA:15.09±0.10(Predicted) 
  • Flash Point:252.313 °C 
  • PSA：84.64000 
  • Density:1.397 g/cm3 
  • LogP:2.89968 

RU 58841(Cas 154992-24-2) Usage

Description

 RU58841, also known as PSK-3841 or HMR-3841, is a potent androgen receptor inhibitor developed by the French pharmaceutical company Roussel Uclaf. It is classified as a nonsteroidal antiandrogen (NSAA) and is primarily used to treat androgenetic alopecia, commonly known as male pattern baldness. HEALTHTIDE BIOTECH CO., LTD. is a dynamic biotechnology company focused on the production and sales of plant extracts, chemical raw materials, food additives, and cosmetic ingredients. With overseas warehouses strategically located in Canada, Germany, the Netherlands, Australia, and Mexico, the company maintains a robust inventory of best-selling products to enhance customer service. Committed to providing high-quality products and efficient shipments, HEALTHTIDE offers door-to-door delivery, customs clearance, and product customization, ensuring clients receive the best value for their research budgets. Since its establishment in November 2020, the company has achieved significant milestones, including a 50% customer buyback rate and a 99% positive feedback rate, driven by a professional and dedicated team that fosters long-term relationships with clients.
Uses RU58841 has been shown to effectively inhibit the hair-thinning effects of DHT, increase the percentage of hair growth in the anagen phase, and improve hair density and diameter. Unlike some other antiandrogen medications, RU58841 is believed to have minimal systemic side effects, making it a promising treatment option for androgenetic alopecia. In addition to its use in treating male pattern baldness, RU58841 has been investigated for potential applications in other androgen-dependent conditions such as acne and excessive hair growth. Its chemical structure is similar to other NSAAs such as nilutamide, flutamide, bicalutamide, and enzalutamide.

InChI:InChI=1/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3

154992-24-2 Relevant articles

Significance of RU58841 as a therapeutic agent effecting androgen receptor molecular interactions in human hair follicles.

Marty E. Sawaya, William I. Roth, Oscar Hevia, Franklin P. Flowers

, Journal of Investigative Dermatology > 1995 > 104 > 4 > 606

RU58841 displayed a promising activity profile when tested with AR purified from HF, giving a calculated K i 0.4 nM, inhibiting approximately 70% DHT/R1881 binding, approximately 20% better than cyproterone acetate. In short term studies we have developed cell free systems using nuclei from human scalp versusgenital skin to assess binding of AR-58841-inhibitor complexes to nuclear chromatin acceptor sites, while measuring stimulation and inhibition of RNA polymerase II, respectively.

Prevention of acne, hirsutism, and baldness in experimental animal models by the topical application of RU 58841, a pure non-steroidal androgen receptor inhibitor.

Jonathan R. Matias, Martine Gaillard

, Journal of Investigative Dermatology > 1995 > 104 > 4 > 577

When applied topically on the ventral pinna of sexually mature male Syrian hamsters for 4 weeks, RU 58841 produced a dose dependent decrease in SG size, with maximum reduction of 60% occurring at a dose of 10 μg per day. The long-haired Syrian hamster (LHS) hamster carries a recessive mutation (ll / ll) of the hair coat. Hair growth in the LHS hamster is sexually dimorphic and androgen dependent.

RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

T. Battmann, A. Bonfils, C. Branche, J. Humbert, F. Goubet, G. Teutsch, D. Philibert

, The Journal of Steroid Biochemistry and Molecular Biology Volume 48, Issue 1, January 1994, Pages 55-60

In intact rats, no effects were observed up to 1 mg animal whatever the route of administration. These results suggest that RU 58841 might be useful for the topical treatment of androgen-dependent skin disorders such as acne, androgenic alopecia and hirsutism.

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