What is the iRGD peptide?

iRGD peptide is , while it's Molecular Formula is C35H57N13O14S2.

What is the CAS number for iRGD peptide?

The CAS number of iRGD peptide is 1392278-76-0.

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iRGD

Product Name: iRGD
CasNo: 1392278-76-0
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CasNo： 1392278-76-0

Molecular Formula： C35H57N13O14S2

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Molecular Formula:C35H57N13O14S2
Molecular Weight:948.0

iRGD (Cas 1392278-76-0) Usage

Description	iRGD Peptide is a 9-amino acid cyclic peptide with the sequence CRGDKGPDC. It is recognized for its potential applications in cancer imaging and as a therapeutic agent for various cancers.
In Vivo Screening	Identified through an in vivo screening of phage display libraries in tumor-bearing mice. Molecular mimicry agent with tumor-targeting properties.
Cyclic Peptide	iRGD is a cyclic peptide consisting of nine amino acids. Derived from RGD peptides.
Binding to Integrins	Binds to αvβ3 and αvβ5 integrins. Integrins are overexpressed in both tumors and blood vessels associated with tumors.
Tissue Penetration	Triggers tissue penetration by binding to av integrins. Cleaves in the tumor to produce CRGDK/R. CRGDK/R interacts with neuropilin-1, facilitating tumor penetration.
Tumor Targeting	Targets tumor blood vessels. Enhances drug delivery deep into tumors.
Extravascular Tumor Tissue	Spreads more extensively into extravascular tumor tissue compared to standard RGD peptides.

1392278-76-0 Relevant articles

iRGD as a tumor‑penetrating peptide for cancer therapy (Review)

Hong Yin Jie Yang Qing Zhang Haiyu Wang Jinjing Xu Junnian Zheng

, MolecularMedicineReports, March 30, 2017 Pages: 2925-2930

The iRGD peptide can be readily synthesized, exhibits significantly improved penetration, compared with traditional peptides, and can effectively inhibit tumor metastasis. Studies in previous years have demonstrated the potential of the iRGD protein for tumors diagnosis and targeted treatment, which warrants further investigation.

Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging

Yunpeng Ye †, Lei Zhu †, Ying Ma, Gang Niu, Xiaoyuan Chen

, Bioorganic & Medicinal Chemistry Letters Volume 21, Issue 4, 15 February 2011, Pages 1146-1150

In this study, two new near-infrared fluorescent iRGD conjugates, that is, Ac-Cys(IRDye®800CW)-iRGD (1), and its dual labeling analog DOTA-Cys(IRDye®800CW)-iRGD (2) were synthesized via the specific mercapto–maleimide reaction for tumor imaging.

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