What is the HUMAN LONG R3IGF-I?

HUMAN LONG R3IGF-I is , while it's Molecular Formula is .

What is the CAS number for HUMAN LONG R3IGF-I?

The CAS number of HUMAN LONG R3IGF-I is 61912-98-9.

Product classification

Featured Products

HUMAN LONG R3IGF-I

Product Name: HUMAN LONG R3IGF-I
CasNo: 61912-98-9
Purity:
Appearance:

Mobile/Wechat/WhatsApp: +852 61915425

Email:niki@healthtide-api.com

Inquiry

CasNo： 61912-98-9

Factory Supply 61912-98-9 with Cheapest Price, Sale HUMAN LONG R3IGF-I

Molecular Formula:C107H214O36
Molecular Weight:2076.8g/mol

HUMAN LONG R3IGF-I (Cas 61912-98-9) Usage

Definition	HUMAN LONG R3IGF-I, also known as Long R3 IGF-I, is a recombinant analog of insulin-like growth factor (IGF) that contains the complete human IGF-I amino acid sequence with a substitution of Arg for Glu3. This modification enhances its stability and potency.
Purpose and Engineering	Specifically engineered for use in biopharmaceutical protein production in mammalian cells.
Growth Support	Capable of supporting the growth and survival of Chinese hamster ovary cells in serum-free media. Demonstrates potency at concentrations at least 200-fold lower than required for insulin.
Potency in Cell Culture	Acts as a more potent growth and survival factor than insulin or native IGF-I in the serum-free culture of human embryonic kidney (HEK293) cells.
Structural Features	Recombinant human insulin-like growth factor (IGF). Consists of 83 amino acids with a 13 amino acid extension peptide at the N-terminus.
Uses	Long R3 IGF-I is specifically designed for use in mammalian serum-free cell culture to promote cell growth and survival. It has a prolonged half-life compared to native IGF-I, making it more effective in stimulating cellular proliferation and survival in vitro.

61912-98-9 Relevant articles

Insulin-Like Growth Factor I (IGF-I) and Long R3IGF-I Differently Affect Development and Messenger Ribonucleic Acid Abundance for IGF-Binding Proteins and Type I IGF Receptors in in Vitro Produced Bovine Embryos*

Katja Prelle, Miodrag Stojkovic, Katja Boxhammer, Jan Motlik, Dagmar Ewald, Georg J. Arnold, Eckhard Wolf

, Endocrinology, Volume 142, Issue 3, 1 March 2001, Pages 1309–1316,

The affinity of LR3 to IGFBPs measured by competition assays and Western ligand blots is at least 3 orders of magnitude lower than that of IGF-I. LR3 was most efficient in stimulating early embryonic cleavage, whereas further development was most potently supported by IGF-I.

IGF-I but not the IGF-I variant Long R3IGF-I increases serum IGFBP-3 in adolescent monkeys

M.E. Wilson, S.L. Lackey

, Growth Hormone & IGF Research Volume 10, Issue 1, February 2000, Pages 37-44

Previous work in rhesus monkeys has shown that both acute or chronic subcutaneous (s.c.) administration of insulin-like growth factor (IGF)-I elevates serum concentrations of IGF binding protein (IGFBP)-3. In order to determine whether an analog of IGF-I, which has a reduced affinity for the IGFBPs, has similar effects, a series of studies using adolescent female rhesus monkeys were conducted.

Home

About us123

Products123

Polypeptide

chemical materials

API

News123

Contact Us123