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CasNo: 12020-86-9
Molecular Formula: FMg O5 Si2 . 1/2 K . 1/2 Li
Description |
Mechano Growth Factor (MGF) is a peptide hormone produced in muscles in response to mechanical stress or training. It plays a role in satellite cell activation and protein synthesis, contributing to muscle repair, growth, and hypertrophy. Researchers are investigating its potential therapeutic applications, especially in conditions involving muscle loss and wasting. |
Uses |
MGF appears to play a dual role in inducing satellite cell activation and promoting protein synthesis. |
Source and Production | It is produced in muscles in response to mechanical stress or training. |
Relation to IGF-1 | MGF is considered an isoform of IGF-1 (Insulin-like Growth Factor-1). |
Potency in Muscle Hypertrophy | MGF is noted to be more potent than the liver type or IGF-IEa in inducing rapid muscle hypertrophy. |
Function in Muscle Repair and Development | Animal studies suggest that MGF peptide may promote tissue repair and development by activating muscle stem cells and increasing protein synthesis for tissue growth. |
Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
The response of insulin-like growth factor-1 (IGF-1) signalling and the capacity of skeletal muscle to adapt to mechanical overload was studied using synergistic muscle ablation.