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MGF

  • Product Name: MGF
  • CasNo: 12020-86-9
  • Purity:
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CasNo: 12020-86-9

Molecular Formula: FMg O5 Si2 . 1/2 K . 1/2 Li

Chinese Manufacturer Supply 12020-86-9 Efficient Transportation, Factory Sells MGF

  • Molecular Formula:FMg O5 Si2 . 1/2 K . 1/2 Li
  • Molecular Weight:

MGF(Cas 12020-86-9) Usage

Description

Mechano Growth Factor (MGF) is a peptide hormone produced in muscles in response to mechanical stress or training. It plays a role in satellite cell activation and protein synthesis, contributing to muscle repair, growth, and hypertrophy. Researchers are investigating its potential therapeutic applications, especially in conditions involving muscle loss and wasting.

Uses

MGF appears to play a dual role in inducing satellite cell activation and promoting protein synthesis.
Source and Production It is produced in muscles in response to mechanical stress or training.
Relation to IGF-1 MGF is considered an isoform of IGF-1 (Insulin-like Growth Factor-1).
Potency in Muscle Hypertrophy MGF is noted to be more potent than the liver type or IGF-IEa in inducing rapid muscle hypertrophy.
Function in Muscle Repair and Development Animal studies suggest that MGF peptide may promote tissue repair and development by activating muscle stem cells and increasing protein synthesis for tissue growth.

12020-86-9 Relevant articles

Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation

Shi Yu Yang, Geoffrey Goldspink

, FEBS Letters Volume 522, Issues 1–3, 3 July 2002, Pages 156-160

Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload

Vivian Owino, Shi Yu Yang, Geoffrey Goldspink

, FEBS Letters Volume 505, Issue 2, 14 September 2001, Pages 259-263

The response of insulin-like growth factor-1 (IGF-1) signalling and the capacity of skeletal muscle to adapt to mechanical overload was studied using synergistic muscle ablation.

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